Your Liver on Histamine

x ray of human body showing the liver highlighted in red

The liver plays an important role in breaking down histamine. Any damage or impairment of this organ may lead to excessive levels of histamine inflammation in the body, while too much histamine triggers elevated liver enzymes. This is your liver on histamine.

WHAT DOES THE LIVER ACTUALLY DO?

The liver’s job is to identify toxic substances and turn them into a harmless product that can be expelled from the body. Liver also contains a type of tissue that transports blood cells. The liver is in constant communication with the digestive system regarding the level of nutrients in the body, or perceived threats like medications, heavy metals and toxic substances.

The liver also regulates our blood supply.

It stores blood, helps us clot, and breaks down damaged cells so they can be flushed out.

This organ is one of the first to get involved when we’re infected with something nasty.

SYMPTOMS OF IMPAIRED LIVER FUNCTION

Fatigue

Weight loss

Lack of appetite

Nausea

Pain the the upper right side of the belly

Enlarged liver

Elevated liver enzymes

Dark pee

Please contact your medical professional if you suspect liver impairment

THE LIVER ON HISTAMINE

Researchers found that patients with liver disease have chronically elevated histamine levels as a result of mast cell activation. Those in the study had itchy, rashy skin.

And as with everything histamine related, it’s a case of chicken and egg, because excess blood histamine has been found to cause liver enzyme fluctuations (I know a lot of you write to me asking about this).

Mast cells are found in normal livers, but in alcoholism they play a role in the development of liver disease.

Mast cells are a part of the white blood cells that make up the immune system. They contain histamine and other inflammatory agents that they release to begin the healing process when we’re injured or sick.

Histamine is the first responder. 

In one study researchers found that in a group of mast cell patients (mast cells release histamine):

75% had elevated cholesterol (patients were not overweight)

Just under 50% had elevated liver enzymes.

Alterations of the bile flow from liver was also found.

A study on ageing found that mast cells could have either a positive or negative impact on how the liver fares in later years (perhaps depending on how many medications it needs to deal with?). The study concluded that mast cell numbers in the liver are an important marker of chronic liver inflammation.

CLICK HERE TO CREATE YOUR OWN HISTAMINE BALANCED DIET AND HEALING PLAN

HOW TO DETOX & PROTECT THE LIVER

Milk thistle

Dandelion

Antioxidants

Vitamin E

Betaine

SAMe

Exercise: An animal study found that alcoholic rats (don’t ask, really) who ran, still had fattier livers than their teetotal colleagues. But the alcohol was no longer causing inflammation in the runners, thanks to their newly raised metabolism and mitochondrial boost.

Sulfurophane: likely the strongest available detoxifier of the liver. High in gluthione and also a very strong cancer cell killer. This compound (research suggests whole broccoli sprouts grown for just 48 hours are most effective) has been found to reverse liver damage.

FRUCTOSE & YOUR LIVER

I myself was worried for some time about the effect of all fructose on the liver. You probably remember a bunch of wellness people telling us we’d made a mistake with agave and coconut sugar, in thinking that they’re any better for us than white sugar. While yes, it’s correct that fructose is bad for the liver, creating fatty tissue and elevated liver enzymes. According to a review of published research by Dr. Michael Greger, New York Times bestselling author of “How Not to Die”, that applies only to industrialised/processed fructose. Whole fruit, served with its fiber, did not have the same detrimental effect on the liver.

It’s not clear to me if coconut sugar falls into this highly processed category, but for now it remains in my (rare) baked recipes. I’ve found that combining it with monk fruit sweetener cuts down on the total carbohydrates and sugars.

MY EXPERIENCE

I’ve never been diagnosed with elevated liver enzymes but I did suffer from a very bizarre, and debilitating, stabbing pain in the liver area. It went on for years, before lessening in intensity and then disappearing for good.

During my months long grueling treatment for the rare breast cancer (which I believe is the result of chemical exposure while covering war zones as a journalist), that I’m now in remission from, I was told to expect some kind of liver impairment or lasting damage.

I drank broccoli sprout juice as often as I could, loaded up on healing antioxidants found in spades in my Man Food cookbook and in my online workshop Beyond the Low Histamine Diet, and had no abnormal results throughout the aggressive treatment. While many factors are obviously at play, diet and exercise combined helped protect my liver, and judging by my test results, the rest of me too!

 

Check out my FAVORITE Book to date… Anti-Recipe! (formerly Man Food).

A high nutrient antihistamine and anti-inflammatory ingredient filled book geared towards anyone who loves to work out, yoga like they mean it, or just load up on healing nutrients. Features my personal shopping list of antihistamine and anti-inflammatory foods.

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——REFERENCES——

Nebert, Daniel W. “Primary Liver, Hepatoma, And Lymphocyte Cultures Used As Models For Studying Genetic Regulation Of Drug Metabolism.” Abstracts (1977): 22. Web.

 Gittlen, S. D., E. S. Schulman, and W. C. Maddrey. “Raised histamine concentrations in chronic cholestatic liver disease.” Gut. U.S. National Library of Medicine, Jan. 1990. Web. 27 July 2017.

 “Cirrhosis.” University of Maryland Medical Center. N.p., n.d. Web. 27 July 2017.

 “How to Improve Liver Function in 6 Steps.” Dr. Axe. N.p., 22 June 2017. Web. 27 July 2017.

 Farrell, D. J., J. E. Hines, A. F. Walls, P. J. Kelly, M. K. Bennett, and A. D. Burt. “Intrahepatic mast cells in chronic liver diseases.” Hepatology (Baltimore, Md.). U.S. National Library of Medicine, Oct. 1995. Web. 27 July 2017.

 Jarido, V., L. Kennedy, L. Hargrove, J. Demieville, J. Thomson, K. Stephenson, and H. Francis. “The emerging role of mast cells in liver disease.” American journal of physiology. Gastrointestinal and liver physiology. U.S. National Library of Medicine, n.d. Web. 27 July 2017.

 Grizzi, Fabio, Giuseppe Di Caro, Luigi Laghi, Paul Hermonat, Paolo Mazzola, Diane D. Nguyen, Saba Radhi, Jose A. Figueroa, Everardo Cobos, Giorgio Annoni, and Maurizio Chiriva-Internati. “Mast cells and the liver aging process.” Immunity & Ageing. BioMed Central, 07 Mar. 2013. Web. 27 July 2017.

 Smith, Brittany. “Here’s the Best Exercise to Protect Your Liver From Too Much Booze.” Men’s Fitness. Men’s Fitness, 16 Mar. 2016. Web. 27 July 2017.

 Kikuchi, Masahiro, Yusuke Ushida, Hirokazu Shiozawa, Rumiko Umeda, Kota Tsuruya, Yudai Aoki, Hiroyuki Suganuma, and Yasuhiro Nishizaki. “Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects.” World Journal of Gastroenterology. Baishideng Publishing Group Inc, 21 Nov. 2015. Web. 27 July 2017.

 Oguz, A., M. Kapan, I. Kaplan, U. Alabalik, B. V. Ulger, O. Uslukaya, A. Turkoglu, and Y. Polat. “The effects of sulforaphane on the liver and remote organ damage in hepatic ischemia-reperfusion model formed with pringle maneuver in rats.” International journal of surgery (London, England). U.S. National Library of Medicine, June 2015. Web. 28 July 2017.
FACLM, Michael Greger M.D. “If Fructose is Bad, What About Fruit?” NutritionFacts.org. N.p., n.d. Web. 28 July 2017.
 Alfter, K., I. Von, B. Haenisch, T. Frieling, A. Hülsdonk, U. Haars, A. Rolfs, G. Noe, U. W. Kolck, J. Homann, and G. J. Molderings. “New aspects of liver abnormalities as part of the systemic mast cell activation syndrome.” Liver international : official journal of the International Association for the Study of the Liver. U.S. National Library of Medicine, Feb. 2009. Web. 28 July 2017.