Is it Getting Hot in Here? Histamine Affects Body Temperature
“Is it just me or is it really hot in here? Or cold? I’m now so cold that I’m shivering,” does this sound familiar? My doctors and I have been quite convinced that I hit peri-menopause in my teens, and yet all blood tests came back 100% normal. After driving significant others to despair with my furnace like heat while asleep (despite claiming I’ve been freezing all day), I finally had an answer. Histamine, of course, affects body temperature, regulates metabolism, and appetite. Because of this, histamine is linked to obesity, but also to anorexia. It’s enough to drive you crazy really. Just when it seems like you’ve got a handle on histamine, it does its usual Dr. Jekyll and Mr. Hyde schtick on you again, and we’re unsure which way is up. Histamine influences body temperature by acting on H1 and H3 receptors. Translation: in order to make use of histamine, the body has histamine receptors numbering 1 to 4. They’re found all over the body, in places like the brain, heart and even breasts. Antihistamine medications can block some, but not all of the receptors. Meaning that even if you’re taking antihistamines, they don’t block all the receptors from being affected by histamine, and so we can still have histamine inflammation symptoms while on these medications. H1 antihistamines are Claritin and Zyrtec. H2 is Zantac for example.