How Histamine Causes Leaky Gut
- Autoimmune disease
- Eczema and psoriasis
- Inflammatory bowel disease
- Acid reflux
- In checking the UK National Health Service (NHS) website as I sometimes do for more information, I found the following statement:
- “While it’s true that some conditions and medications can cause a “leaky” gut (what scientists call increased intestinal permeability), there is currently little evidence to support the theory that a porous bowel is the direct cause of any significant, widespread problems.”This directly contradicts the numerous studies out there.
How histamine and mast cells affect our intestinal barrier and trigger permeability/leaking
- An animal study showed that histamine increased permeability of the intestines. Pre-Treatment with an H1 receptor antagonist (an antihistamine similar to Claritin and Zyrtec for example) didn’t stop this, but an H2 antagonist (a stomach medicine which is also an antihistamine like Zantac/Ranitidine) did prevent the intestinal permeability.
- Researcher from another tells us that Interleukin-9 (released by mast cells) is involved in intestinal permeability/leaky gut, and that this process plays an important role in food allergy.
“‘Bacteria’ or ‘Yeast’ is a kingdom of organisms, in the same way that humans belong to the ‘Animal’ kingdom. The bacteria can then be separated out into different groups based on similar characteristics, with increasing detail down through the phylum, class, order and family, until the genus level is reached e.g. lactobacillus. Within the genus level is the species level e.g. acidophilus (for humans the equivalent would be Homo sapiens).